arav-8k_20191202.htm

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 27, 2019

 

Aravive, Inc.

(Exact name of registrant as specified in its charter)

 

 

Delaware

 

001-36361

 

26-4106690

(State or other jurisdiction

of incorporation)

 

(Commission

File Number)

 

(IRS Employer

Identification No.)

 

River Oaks Tower

3730 Kirby Drive, Suite 1200

Houston, Texas 77098

(Address of principal executive offices)

 

(936) 355-1910

(Registrant’s telephone number, including area code)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class

 

Trading
Symbol(s)

 

Name of each exchange
on which registered

Common stock, par value $0.0001 per share

 

ARAV

 

Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.

 


 


 

Item 8.01. Other Events.

Pursuant to the terms of the Purchase Agreement dated November 27, 2019 by and among Aravive, Inc. (the “Company”) and Piper Jaffray & Co. and Cantor Fitzgerald & Co., as representatives of the several underwriters named therein (the “Underwriters”), the Underwriters were granted an over-allotment option to  purchase up to an additional 500,000 shares of the Company’s common stock, par value $0.0001 per share (the “Common Stock”), in connection with the previously announced public offering.  On November 27, 2019, the Underwriters partially exercised such option with respect to 300,000 shares of the Company’s Common Stock (the “Option Shares”).

On December 2, 2019, the Company closed the public offering including the sale of the Option Shares. After giving effect to the partial exercise of the over-allotment option, the total number of shares of Common Stock sold by the Company in the public offering was 3,633,334 shares of Common Stock and total gross proceeds to the Company, before deducting underwriting discounts and commissions and other offering expenses payable by the Company, were approximately $27.25 million.

In addition, the Company will be making several investor presentations over the next several weeks, including investor presentations at the 2019 Piper Jaffray Healthcare Conference to be held on Wednesday, December 4, 2019 in New York, New York. In connection with the presentations, the Company intends to discuss the investor presentation attached as Exhibit 99.1 hereto, which is incorporated herein by reference.

 

The investor presentation attached as Exhibit 99.1 to this Current Report on Form 8-K includes “safe harbor” language pursuant to the Private Securities Litigation Reform Act of 1995, as amended, indicating that certain statements contained in the investor presentation are “forward-looking” rather than historical.

 

The Company undertakes no duty or obligation to update or revise information included in this Current Report on Form 8-K or the investor presentation attached as Exhibit 99.1 hereto.

 

Item 9.01.  Financial Statements and Exhibits.

(d) Exhibits.

The following exhibit is filed with this Current Report on Form 8-K:

 

 

 

 

Exhibit
Number

  

Description

 

 

99.1

  

Aravive, Inc. Investor Presentation dated December 2019


 


 

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

Date: December 2, 2019

ARAVIVE, INC.

(Registrant)

 

 

 

By:

 

/s/ Jay P. Shepard

 

Name:

 

Jay P. Shepard

 

Title:

 

Chief Executive Officer

 

 

 

arav-ex991_50.pptx.htm

Slide 1

Halting Disease Progression in its Tracks © 2019 Aravive, Inc. Aravive Corporate Presentation December 2019 Exhibit 99.1

Slide 2

Important Information © 2019 Aravive, Inc. Forward-Looking Statements This presentation contains forward-looking statements that may discuss Aravive’s plans, goals, intentions and expectations as to future trends, events, results of operations, financial condition or other matters. Forward- looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and they often include words such as “may,” “will,” “should,” “would,” “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions. Statements that are not historical facts are forward-looking statements. Forward-looking statements included in this presentation include statements regarding Aravive’s planned clinical activities, including the design, initiation, patient enrollment and availability of data from clinical studies, future indications and cash position and the anticipated safety, activity and manufacturability of Aravive’s product candidates. Forward-looking statements are based on Aravive’s current beliefs and assumptions, are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, without limitation: the unpredictability of clinical development activities; risks related to Aravive’s ability to estimate and control its operating expenses; Aravive’s ability to protect its intellectual property rights; changes in the competitive environment; and legislative, regulatory, political and economic developments. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in Aravive’s most recent Annual Report on Form 10-K and 10-K/A, subsequent Quarterly Report on Form 10-Q and Current Reports on Form 8-K filed with the Securities and Exchange Commission. Except as required by law, Aravive undertakes no obligation to revise or update any forward-looking statement or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.

Slide 3

Company Overview The Company Lead Clinical Program (AVB-500) Aravive is a clinical stage company developing treatments designed to halt the progression of life-threatening diseases, including cancer and fibrosis NASDAQ-listed company (ARAV) Offices in Houston, TX (hdqtrs.) and Palo Alto, CA $20 million Product Development Award from the Cancer Prevention & Research Institute of Texas (CPRIT) Led by a team of industry veterans with decades of target biology, drug development, & commercialization expertise Multiple clinical and program milestones during 2020 A first-in-class, ultra-high affinity, Fc-fusion protein designed to selectively block the novel GAS6-AXL signaling pathway Proof-of-mechanism established in clinic using proprietary biomarker for target engagement Early proof-of-concept for anti-tumor activity demonstrated in platinum-resistant ovarian cancer Currently in expanded Phase 1b/2 for platinum-resistant ovarian cancer; Fast-track designation granted by the FDA Ideal profile for combination with chemo, check-point inhibitors and PARP inhibitors in broad range of indications IP coverage through 2033 and beyond Our approach draws on novel insights into targeting signaling pathways that drive the activation, migration and invasion of abnormal cells into healthy tissues © 2019 Aravive, Inc.

Slide 4

Pipeline Focused on GAS6/AXL Signaling in Oncology & Fibrosis Indication Preclinical Phase 1 Phase 1*Phase 1b Phase 2 Phase 3 AVB-S6-TBD Ovarian Cancer platinum resistant Clear Cell Renal Cancer 3rd Oncology (undisclosed indication) Kidney Fibrosis (IgAN) Chronic Fibrosis (undisclosed indication) AVB-500 Status: P1b/P2 Initiation expected 4Q19/1Q20 Status: P1b expansion to confirm early efficacy Status: Initiation expected 4Q 2019 © 2019 Aravive, Inc. Ovarian Cancer platinum resistant (PD-L1i combo; AZ; IST) Status: Recruiting 4Q2019 IST= investigator sponsored trial

Slide 5

AXL Tyrosine Kinase Promotes Invasion, Metastasis, and Resistance AXL is a member of tyrosine kinases that include Tyro3, AXL, and Mer (TAMs) AXL is activated by a single ligand, growth arrest–specific 6 (GAS6); Mer and Tyro3 can be activated by GAS6 and Protein S 1 Upregulated in many cancers 2, AXL overexpression linked to metastasis 3,4, poor survival 5-7, and drug resistance 8,9 Unusually strong binding affinity between GAS6 and AXL of ~ 30 pM makes development of inhibitors to the pathway challenging 1 1 J Clin Invest. 2017;127(1):183–198. 2 Adv Cancer Res. 2008;100:35–83. 3 Oncogene. 2009;28(39):3442–3455 4 Cancer Res. 2010;70(19):7570–7579 5 Proc Natl Acad Sci U S A. 2006;103(15):5799–5804 6 Ann Diagn Pathol. 2013;17(5):425–429 7 Proc Natl Acad Sci U S A. 2010;107(3):1124–1129 8 Nat Genet. 2012;44(8):852–860 9 Cancer Res. 2013;73(1):331–340 Figure from Clinical Science Apr 01, 2012, 122 (8) 361-368

Slide 6

GAS6/AXL Signaling: Decoy Receptor is the Best Approach for Potent and Selective Inhibition WT AXL has pM Affinity; AVB-500 AXL Decoy has fM Affinity Selectivity limited by RTK homology Off-target toxicity Multiple resistance mechanisms Many potential competitors Decoy AXL Receptor AXL or GAS6 Antibody Tyrosine Kinase Inhibitor Requires a mAB affinity that competes with receptor Not achievable for AXL Many potential competitors Binds more tightly to GAS6 than WT AXL Complete target coverage with no anticipated off-target toxicity First-in-Class with strong IP position kinase domain © 2019 Aravive, Inc.

Slide 7

Other Drugs Targeting AXL Signaling in Clinical Development are Not Selective Drug (Stage) Company Target Selective for AXL AVB-500 (Ph Ib/II) Aravive GAS6 YES Gilterinib (Market) Astellas AXL NO Cabozantinib (Market) Exelixis AXL NO Sitravatinib (Ph III) Mirati (BeiGene) AXL NO Merestinib (Ph II) Lilly AXL NO BGB324 (Ph II) BergenBio AXL NO S49076 (Ph i/II) Servier AXL NO TP-0903 (Ph I/II) Tolero (Sumitomo) AXL NO BPI-9016M (Ph I) Betta Pharmaceuticals AXL NO ONO-7475-01 (Ph I) Ono Pharmaceuticals AXL NO RXDX-106 (Ph I) Ignyta AXL NO © 2019 Aravive, Inc. VS.

Slide 8

AVB-500 Inhibits AXL Signaling by Neutralizing GAS6, Sole Ligand for AXL Decoy receptor engineered for very high affinity for GAS6 – ~200 fold greater than native AXL Favorable safety and PK profile GAS6 not needed by normal tissue GLP preclinical studies demonstrate ≥ 30-fold safety margin (relative to max feasible dose in tox; 3-month tox study completed) As biologic, does not compete for metabolism with chemotherapies; facilitates combination with other therapies Small molecules targeting AXL can have off target activities Strong IP position on GAS6 inhibition Proprietary biomarker tests to monitor GAS6 levels; serum GAS6 levels associated with efficacy in preclinical studies Robust CMC Drug candidate manufactured at high yield and purity AVB-S6-500 Demonstrated Favorable Safety Profile and Proof-of-Mechanism in FIH Phase 1 Trial J Clin Invest. 2017;127(1):183–198

Slide 9

GAS6/AXL Signaling is Critical in Resistant Metastatic Ovarian Cancer Expression in 0% (0/10) of normal ovarian tissue Expression in 73% (219/297) ovarian tumor samples including low grade serous, endometroid and advanced stage tumors1 Preclinical in vitro 1,2,3 Inhibition decreases invasion/migration Preclinical in vivo 1,2,3 Inhibition decreases tumor Correlates with chemoresistance to carboplatin and paclitaxel Inhibition improves sensitivity to platinum and taxane therapies Rankin et al, Cancer Res. Oct 1; 70 (19) 2010 Divine et al, Oncotarget 7 (47) 2016; Quinn et al, Mol Cancer Ther November 26 2018; Kariolis et al, J Clin Invest. 2017 Quinn et al. Mol Cancer Therapeutics 2019

Slide 10

AVB-500: A Novel Lead Clinical Program With Attractive Attributes Fast-track designation granted by the FDA for platinum-resistant ovarian cancer; currently in expanded Phase 1b/2 trial with early proof-of-concept data Well-tolerated to date and no anticipated drug-drug interactions facilitate combination studies (unlike small molecules) The ability to combine with common standards of care allows access to a large total accessible market Robust chemistry manufacturing control with high yield and purity © 2019 Aravive, Inc.

Slide 11

AVB500-OC-002: A P1b Study of AVB-500 in Combination with Single Agent Chemotherapy in Platinum-Resistant Ovarian Cancer Key Eligibility Criteria 1-3 prior lines Measurable disease Platinum free interval ≤ 6mo after most recent platinum-containing regimen Adenocarcinoma NOS, high grade endometroid adenocarcinoma, mixed epithelial (≥ 80% high grade serous), high grade serous, or undifferentiated carcinoma ECOG performance status 0-1 Goals for expansion: 1. Safe & tolerated 2. AVB serum biomarker targets met Expansion Cohort PAC: n = 18 PLD: n = 18 AVB + PLD n=6 AVB + PAC n=6 AVB-500 (AVB): Initial dose 10 mg/kg q14 days Pegylated liposomal doxorubicin (PLD): 40 mg/m2 d1; 28 day cycle Paclitaxel (PAC): 80 mg/m2 day 1, day 8, day 15; 28-day cycle NOS= Not Otherwise Specified ECOG= Eastem Cooperative Oncology Group Trial Design (NCT03639246) © 2019 Aravive, Inc.

Slide 12

Safety data for the first 31 patients: AVB-500 (10mg/kg) well-tolerated No serious and unexpected adverse reactions No dose limiting toxicities Infusion reactions managed by premedication regimen 40 patients total have been dosed at 10mg/kg Similar safety profile as that seen with first 31 patients Additional 3 patients have been dosed at 15mg/kg To date, similar safety profile to the 10mg/kg dose © 2019 Aravive, Inc. Safety Summary from Phase 1B to Date

Slide 13

Efficacy Outcomes to Date from Phase 1b Study More Mature Data on 31 Evaluable Patients As of Oct 31 2019 31 Patients First 12 Patients Next 19 Patients Complete Response (CR) + Partial Response (PR) 7 (22%) 5 (42%) 2 (10%) Stable Disease (SD) 13 (42%) 2 (16%) 11 (58%) CBR (SD+CR+PR) 20 (64%) 7 (58%) 13 (68%) Progressive Disease (PD) 11 (35%) 5 (42%) 6 (32%) Both stable disease and response influence progression free survival (PFS) times Response Determined by Investigator-Assessed RECISTv1.1

Slide 14

Identifying Minimal Efficacious Concentration Efficacy Related to Amount of AVB-500 in the Body Investigated the difference between the patients who received 10mg/kg and had clinical benefit (stable disease or response) vs those who did not benefit at this same dose. An unsupervised analysis of all variables (including demographics and baseline characteristics and AVB-500 levels in the blood) demonstrated that the only parameters that were significantly associated to efficacy were drug exposure levels (i.e. trough levels and Cmax levels). Initially found statistically significant relationship between Cmax and response With current data from 31 patients, including progression free survival (PFS) and additional PK data, now see strong significance between PFS and Ctrough levels (p=0.0066) Cmax and Ctrough levels do still correlate The analysis identified a minimal efficacious concentration (13.8 mg/L) that is consistent with at least 95% target engagement based on independent PK modeling. Initially targeted 90% target engagement but PROC data suggests 95% needed At the 10 mg/kg dose, 17 of 31 platinum-resistant ovarian cancer patients (approximately 50%) achieved the minimal efficacious concentration after the first dose of AVB-500.  

Slide 15

© 2019 Aravive, Inc. Sufficient AVB-500 Exposures at 10 mg/kg Increased Median PFS 4-fold, from 2 Months to 8 Months Median progression free survival (PFS) will be the primary endpoint for platinum-resistant ovarian cancer trials Median PFS for platinum-resistant ovarian cancer patients given PAC or PLD is 3-4 months but 6-8 weeks in patients with platinum free interval of less than 3 months and/or on 3rd or greater lines of therapy Above Minimal Efficacious Exposure Below Minimal Efficacious Exposure

Slide 16

Exposure-Response Analysis Demonstrated AVB-500 Levels at 10mg/kg Dose Predict Clinical Benefit © 2019 Aravive, Inc.   Above Minimal Efficacious Exposure Below Minimal Efficacious Exposure Number of Patients (n) 17 14 Complete Response (CR) 1 (6%) 0 Partial Response (PR) 4 (24%) 2 (14%) Overall Response Rate (ORR) 5 (29%) 2 (14%) Stable Disease (SD) 9 (53%) 4 (28%) Clinical Benefit (SD+ORR) 14 (82%) 6 (43%) Median DOR (months) 7.6 3.9 Median PFS (months) 8.1 1.8 Progressive Disease (PD) 3 (18%) 8 (57%) Patients remaining on study as of Oct 31 2019 8 (47%) 0 Sufficient AVB-500 exposures doubled ORR, Clinical Benefit Rate, and duration of response Response rate in below minimal efficacious exposure patients consistent with historical control rates of 10-15% for PAC or PLD Best Response Determined by Investigator-Assessed RECIST 1.1

Slide 17

Historical Control Information Cancer Chemotherapy and Pharmacology (2019) 84:33-39 37 European Journal of Obstetrics & Gynecology and Reproductive Biology 166 (2013) 94–98 Prior Lines AVB500-OC-002 Data from Literature (Plat-S/Plat-R not parsed) 2 (N=14) ORR 29% 12% (6.9%CR) CBR 64% 16% 3 (N=8) ORR 25% 2.9% (0 CR) CBR 75% 9% 26% of the 62 patients in the less than 3 mo PFI group had primary refractory disease

Slide 18

Best Response Determined by Investigator-Assessed RECISTv1.1 for First 31 Patients (10mg/kg): One CR Percent Change in Sum of Target Tumors from Baseline to Best Response Note: 2 pts who were PD at best response (Pac arm) are excluded from the waterfall Pac PLD High exposure patients

Slide 19

Summary of First 31 Patients’ Response as of October 31 2019 CT Scans PAC PLD Partial response Progressed Complete response Stable disease represented by continuous bar * * * * * * * * * * * * * * * * * * High exposure patients

Slide 20

Observations on Patients Continuing On Study The patient with CR achieved the minimal efficacious concentration of AVB-500 while on PAC. She had a baseline serum GAS6 level that was typical of the platinum-resistant ovarian cancer population and 2-fold higher than that observed in healthy volunteers. She also exhibited poor prognostic factors, including two prior lines of therapy and PFI less than 3 months. Confirmatory scan will be done in 4 weeks Among the patients who responded to AVB-500, four of seven remain responders and on study, and two patients remain on AVB-500 as single agent. All 4 achieved minimal efficacious AVB-500 concentration. Among the 13 patients whose best response was SD, four who achieved the minimal efficacious concentration of AVB-500 remain on study. One SD patient whose trough level was below the minimal efficacious concentration did not progress but withdrew consent. Eight (47%) of the patients who achieved the minimal efficacious concentration of AVB-500 remain on study versus none of the patients whose trough values were below that concentration. Because the study is still ongoing, DOR and PFS may continue to evolve.

Slide 21

Comparable Demographics and Baseline Characteristics Confirming AVB-500 Exposure Drives Anti-Tumor Activity Above Minimal Efficacious Concentration Below Minimal Efficacious Concentration Age, years median (min, max) 71 (52-82) 63.0 (53-80) Prior lines* 1 (%) 6 (35.3%) 2 (14.3%) 2 (%) 8 (47.1%) 6 (42.9%) 3 (%) 3 (17.6%) 5 (35.7%) Platinum Free Interval ≥ 3mo 11 (64.7%) 8 (57.1%) < 3mo 6 (35.3%) 6 (42.9%) ECOG 0 11 (64.7%) 6 (42.9%) 1 6 (35.3%) 8 (57.1%) * PAC PT IN BELOW MINIMAL EFFICACIOUS GROUP MISSING VALUE

Slide 22

Next Steps Data confirm strategy to investigate higher doses in the current Phase 1b study to determine if a greater proportion of patients achieve high drug exposure levels PK modeling predict a dose of 20 mg/kg should allow >90% of patients to achieve desired high exposure levels Anticipate 18-24 more patients across both cohorts and at 15 and 20mg/kg Will evaluate percentage of patients achieving minimal efficacious concentration and correlate to response rates Anticipate preliminary data read-out middle of 2020 for 15 and 20mg/kg

Slide 23

Platinum-Resistant Ovarian Cancer Phase 2/3 P1b Will Determine RP2D Anticipate initiating 2H20 Same population as P1b portion Effect size from P1b (all AVB-500 doses) will drive regulatory strategy, statistical plan, Ns Randomized (2:1), double-blind, placebo- controlled study to compare efficacy and tolerability of AVB-500 in combination with PLD or Pac versus placebo plus PLD or Pac Primary objective to assess anti-tumor activity of AVB-S6-500 in combination with Pac Or PLD as measure by PFS Secondary objectives include assessment of PK/PD and additional efficacy endpoints (ORR, OS, DOR, DCR) Platinum Resistant Ovarian Cancer 1-3 prior lines PLD SOC + placebo SOC= standard of care; PLD or PAC SOC + AVB-500

Slide 24

Pipeline Focused on GAS6/AXL Signaling in Oncology & Fibrosis Indication Preclinical Phase 1 Phase 1*Phase 1b Phase 2 Phase 3 AVB-S6-TBD Ovarian Cancer platinum resistant Clear Cell Renal Cancer 3rd Oncology (undisclosed indication) Kidney Fibrosis (IgAN) Chronic Fibrosis (undisclosed indication) AVB-500 Status: P1b/P2 Initiation expected 4Q19/1Q20 Status: P1b expansion to confirm early efficacy Status: Initiation expected 4Q 2019 © 2019 Aravive, Inc. Ovarian Cancer platinum resistant (PD-L1i combo; AZ; IST) Status: Recruiting 4Q2019 IST= investigator sponsored trial

Slide 25

Rationale for AVB-500 in Kidney Cancer Strong biological rationale for clear cell Renal Cell Cancer AXL/GAS6 levels predict prognosis & survival in human Strong in vivo Activity in Preclinical models single agent combo with TKI Xiao et al, Cancer Research October 4, 2019; © 2019 Aravive, Inc. Rankin et al, PNAS | September 16, 2014 | vol. 111 | no. 37 | 13375

Slide 26

Rationale for AVB-500 in Kidney Fibrosis GAS6 acts as a mitogen, stimulating mesangial cell proliferation through binding to its cell-surface receptor AXL Mesangial proliferation is a hallmark of IgAN Coppo et al, Kidney Intl (2014) 86:828-36; Reich et al, J Am Soc Nephrol (2007) 3177-83 M. Yanagita, et al. (1999) J Am Soc Nephrol 10: 2503–2509. Yanigati et al, (2001) Am J Pathol. Apr; 158(4): 1423–1432 © 2019 Aravive, Inc. Strong biological rationale for IgA nephropathy (IgAN) GAS6 levels predict prognosis in human Strong in vivo activity in Preclinical models

Slide 27

AXL Promotes a Suppressive Myeloid Micro-environment ISTs Investigating Combinations of AVB-500 + PDL1 inhibitor AXL presence Decreases tumor T cells (killer) infiltration Decreases Tumor antigen presentation Increases suppressive myeloid cells and macrophages AXL loss Increases Tumor antigen expression Decreases suppressive myeloid cells and macrophage Increases Tumor T cell infiltration Sensitizes tumor cells to checkpoint immunotherapy when they were previously resistant AXL expressed in patients unresponsive to PD-1/PD-L1 immunotherapy Adapted from NATURE COMMUNICATIONS | 7:13898 | DOI: 10.1038/ncomms13898 | © 2019 Aravive, Inc.

Slide 28

Experienced, Methodical, Efficient Development Execution Strong Clinical Development Team © 2019 Aravive, Inc. Dev Plan Enabled Bifurcated Strategy- Oncology and Fibrosis 4Q 2017- IND filed 1Q 2018- FIH in NHV initiated 2Q 2018- POM in NHV 3Q 2018- Tolerability in NHV 4Q 2018- P1b in Ovarian Cancer initiated 2Q 2019- POM in Ovarian Cancer 2Q 2019- Tolerability in Ovarian Cancer 3Q 2019- Early POC in Ovarian Cancer 3Q 2019- Expanded P1b Ovarian Cancer 4Q2019- Kidney fibrosis trial initiation 4Q2019/1Q2020- Renal cell carcinoma trial initiation Mid-2020- RP2D established from Ph1b Ovarian (after 15 and 20mg/kg doses) 2H-2020- P2/P3 Platinum-resistant ovarian cancer initiation 2020- Safety and early efficacy in kidney fibrosis Achieved MilestonesUpcoming Milestones FIH=first in human; IND= investigational new drug application; POM=proof of mechanism; POC=proof of concept; R2PD=recommended P2 dose

Slide 29

Financials and Capitalization NASDAQ: ARAV; Shares Outstanding*: 14.9M basic * As of September 30, 2019 as adjusted to include newly issued shares and net proceeds from recent public offering that closed on December 2, 2019. Cash and cash equivalents*: $70M Cash and cash equivalents expected to enable the company to fund its operating plans through 2021 © 2019 Aravive, Inc.

Slide 30

AVB-500 Offers First- and Best-In-Class Opportunity in Oncology and Fibrosis Uniquely positioned in competitive landscape Robust pipeline addressing significant drivers of mortality in oncology and fibrosis: metastasis and drug resistance © 2019 Aravive, Inc. AVB-500: high affinity decoy protein, a potent and selective drug targets GAS6/AXL signaling Validated pathway drives activation, migration and invasion of abnormal cells Suppresses GAS6 to undetectable levels in early clinical studies; prolonged target engagement Safety and tolerability profile to date support use as combination and/or maintenance therapy Compelling early efficacy signal in platinum-resistant ovarian cancer No adverse events that limit dosing High AVB-500 levels predictive of anti-tumor activity; statistically significantly association with PFS (p=0.006568) In first 31 patients, median PFS for patients with high drug levels was 4-fold greater than those with low drug levels (p=0.0016). Expanded P1b portion to validate efficacy signal, evaluate higher doses and explore the most efficient regulatory path to approval Additional programs advancing into the clinic in high need indications Kidney fibrosis (IgA nephropathy) trial initiation anticipated in 4Q 2019 Renal cell carcinoma trial initiation anticipated in 4Q 2019-1Q 2020

Slide 31

Halting Disease Progression in its Tracks © 2019 Aravive, Inc. Thank You