The presentation, “Therapeutic AXL/GAS6 inhibition of tumor and tumor microenvironment stromal cells improves response to chemotherapy in ovarian cancer,” was presented by
“This small, non-clinical study continues to support previous literature that highlights the importance of further clinical studies of agents that can specifically and potently inhibit the GAS6/AXL pathway,” said Dr. Fuh. “In our pre-clinical work, it appears that AVB-500 has the potential to be an important new medicine for women with ovarian cancer.”
Key Study Results:
- Increased serum and tumor GAS6 levels are associated with chemoresistance and decreased progression free survival (PFS) in patients with high-grade serous ovarian cancer undergoing neoadjuvant treatment.
• In patients with high tumor GAS6 expression (>80%, n=7) median PFS was 7.7 months compared to 15.2 months in patients with low tumor GAS6 expression (<35%, n=3).
• In patients with high serum GAS6 levels (>25ng/ml, n=10) median PFS was 9.9 months compared to 20.4 months median PFS in patients with low serum GAS6 levels (<15ng/ml, n=3).
- In vitro and in vivo mouse PDX models demonstrated the combination of AVB-500 with chemotherapy decreases tumor and stromal cell viability, tumor burden, and increases DNA damage.
- The poster will be available online at: https://ir.aravive.com
Forward Looking Statements
This communication contains forward-looking statements (including within the meaning of Section 21E of the United States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended), express or implied, concerning the Company's goals, intentions and expectations as to future plans or events, including statements regarding the potential of AVB-500 to be an important new medicine for women with ovarian cancer the anticipated reporting of interim safety, pharmacodynamic, and pharmacokinetic data for the phase 1b portion in the third quarter of 2019 and the intension to expand development into additional oncology and fibrotic indications. Forward-looking statements are based on current beliefs and assumptions that are subject to risks and uncertainties and are not guarantees of future performance. Actual results could differ materially from those contained in any forward-looking statement as a result of various factors, including, but not limited to, risks and uncertainties related to: the usefulness of circulating free GAS6 as a biomarker of drug activity in the new trial, the Company’s ability to expand development into additional tumor types, AVB-S6-500’s ability to have favorable results in clinical trials or receive regulatory approval, including its ability to meet the primary and secondary endpoint for the Phase 1b portion of the clinical trial and show a clinical benefit against refractory and metastatic cancers; potential delays in the Company's clinical trials due to regulatory requirements or difficulty identifying qualified investigators or enrolling patients; the risk that AVB-S6-500 may cause serious side effects or have properties that delay or prevent regulatory approval or limit its commercial potential; the risk that the Company may encounter difficulties in manufacturing AVB-S6-500; if AVB-S6-500 is approved, risks associated with its market acceptance, including pricing and reimbursement; potential difficulties enforcing the Company's intellectual property rights; the Company's reliance on its licensor of intellectual property and financing needs. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including the risk factors included in the Company's Annual Report on Form 10-K for the fiscal year ended
Source: Aravive, Inc.